Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face transplantation must meet all the ethical requirements (...) usually applied to health care research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and transplantation. Finally, we maintain that the time has come to move facial transplantation research into the clinical phase. (shrink)

Main Response Topics ? Introduction ? Open display and public evaluation ? Publicity versus patient privacy ? Facial tissue donation ? Validity of Louisville Instrument for Risk Acceptance ? Patients' understanding of risk ? Face versus hand transplantation ? Rejection rates/risks ? Patient compliance ? Exit strategy ? Functional recovery ? Societietal implications ? Psychological implications ? Conclusion: Uncertainty likely to persist.

The extent of the dependence of early Greek cosmogony on mythical conceptions has long been a prolific source of controversy. Views on the subject have varied from Professor Cornford's claim that ‘there is a real continuity between the earliest rational speculation and the religious representation that lay behind it’ to Professor Burnet's extreme statement, ‘it is quite wrong to look for the origins of Ionian science in mythological ideas of any kind.’ The solution of the problem that I wish to (...) suggest is one which should satisfy those who insist on ‘the scientific character of the early Greek cosmology,’ while retaining a direct connection with pre-scientific beliefs—namely, that some, at least, of the earliest philosophers founded their doctrines of the beginning of the universe on a deliberate rationalization of earlier and contemporary mythical ideas. The appearance of notions like the ‘world-egg’ in a number of passages, too well known for quotation, shows that primitive cosmogony assumed an analogy between the generation of the world and the generation of animate creatures. I believe it can be proved that, so far from the ‘renunciation of sexual imagery’ which even Professor Cornford has recently attributed to Anaximander, he and other philosophers retained the habit of regarding cosmogony and anthropogony as parallel phenomena, only substituting for the mythical ‘world-egg’ a more scientific view of the embryo and its development. They looked at the world through the same spectacles as their predecessors, but after wiping from them the rose tint of mythological fancy. (shrink)

In this book Professor Baldry describes this development from Homer to Cicero when, although the traditional divisions and prejudices still remained string, the ...

The fundamental tenet of contemporary sociobiology, namely the assumption of a single process of evolution involving the selection of genes, is critically examined. An alternative multiple-level, multiple-process model of evolution is presented which posits that the primary process that operates via selection upon the genes cannot account for certain kinds of biological phenomena, especially complex, learned, social behaviours. The primary process has evolved subsidiary evolutionary levels and processes that act to bridge the gap between genes and these complex behaviours. The (...) subsidiary levels are development, individual animal learning, and socioculture itself. It is argued that individual learning is pivotal to the derivation and biological analysis of culture. The differences between cultural and noncultural societies are stressed. It is concluded that such a multiple-level model of evolution can form the basis for reconciling opposing sides in the sociobiology debate. (shrink)

There are many passages in ancient literature which depict an imaginary existence different from the hardships of real life-an existence blessed with Nature's bounty, untroubled by strife or want. Naturally this happy state is always placed somewhere or sometime outside normal human experience, whether ‘off the map’ in some remote quarter of the world, or in Elysium after death, or in the dim future or the distant past. Such an imaginary time of bliss in the past or the future has (...) become known as the ‘golden age’. This is the name which modern scholars generally give to the ancient belief. The phrase is often echoed by modern poets. The same language has been transferred from the unknown to the known, and it has become a commonplace to describe an outstanding period of history or literature as a ‘golden age’. (shrink)

It is traditionally believed that cerebral activation (the presence of low voltage fast electrical activity in the neocortex and rhythmical slow activity in the hippocampus) is correlated with arousal, while deactivation (the presence of large amplitude irregular slow waves or spindles in both the neocortex and the hippocampus) is correlated with sleep or coma. However, since there are many exceptions, these generalizations have only limited validity. Activated patterns occur in normal sleep (active or paradoxical sleep) and during states of anesthesia (...) and coma. Deactivated patterns occur, at times, during normal waking, or during behavior in awake animals treated with atropinic drugs. Also, the fact that patterns characteristic of sleep, arousal, and waking behavior continue in decorticate animals indicates that reticulo-cortical mechanisms are not essential for these aspects of behavior. (shrink)